HETEROYRYL PYRIDONES AND AZAPIRIDONS WITH ELECTROPHILIC FUNCTIONALITY Russian patent published in 2018 - IPC C07D401/14 C07D495/04 A61K31/5025 A61P35/00 

FIELD: chemical industry.

SUBSTANCE: invention relates to compounds of Formula

I

or pharmaceutically acceptable salts thereof, wherein X¹ is a CR¹ or N; X² is a CR²; X³ represents CR³; R¹, R² and R³ are independently selected from H, F; X⁴ is N; X⁵ represents CH or N; X⁶ and X⁷ represent CH; Y¹ and Y² are CH; Z is O or NR, where R H or C₁-C₃ alkyl; Q is selected from the group having the structure , , where R⁴ selected from -CH=CH₂, -C(CN)=CH₂, -C≡CCH₃ and R⁵ is selected from H and C₁-C₃ alkyl; R^6b, R^7a and R^7b are H; R^6a is H or C₁-C₃ alkyl; or if Z is nitrogen, then Z and R^6a form a five- or six-membered heterocyclic ring; R⁸ is CH₂OH; R⁹ is selected from the following structures: and , useful for the inhibition of Btk, as well as for the treatment of tumors and inflammatory disorders such as inflammation mediated by Btk.

EFFECT: treatment of tumors and inflammatory disorders, such as inflammation mediated by Btk.

27 cl, 127 ex, 3 tbl