PROTEIN TYROSINE KINASE RECEPTOR INHIBITOR COMPOSITIONS Russian patent published in 2016 - IPC C07D405/04 A61K31/423 A61P29/00 

FIELD: medicine.

SUBSTANCE: invention refers to a pharmaceutical composition for TrkA kinase inhibition or antagonism, containing the therapeutically effective amount of the compound of a structural formula (VIa.11) or its pharmaceutically acceptable salt or ester, and at least one pharmaceutically acceptable carrier

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wherein nn represents 0; A₆₄ represents O; A₆₅ represents N; A₆₆ represents NR⁷³; Y represents O; R⁷² represents an optionally substituted C2-C6 alkyl or optionally substituted C6-C10 aryl; wherein a substitution group is specified in -OR^b and -C(O)OR^b, wherein each R^b independently represents hydrogen or C1-C6 alkyl; and R⁷³ represents a C3-C6 cycloalkyl. The invention also refers to using the compound of the structural formula (VIa.11) for treating pain in a patient.

EFFECT: more effective application.

37 cl, 20 tbl, 20 ex