STABILIZED PEMETREXED COMPOSITION Russian patent published in 2017 - IPC A61K31/519 A61K47/20 A61K47/12 A61K9/08 A61P35/00 

FIELD: pharmacology.

SUBSTANCE: composition contains pemetrexed or a pharmaceutically acceptable salt thereof as an active ingredient, N-acetyl-L-cysteine and sodium citrate, wherein the concentration ratio is -30 : 0.15 - 2.0 : 1.0 - 15.0, respectively. The liquid composition can be stored in a solution state. The composition is an injectable liquid composition in an airtight container. The composition is ready for use.

EFFECT: combined use of pemetrexed, N-acetyl-L-cysteine and sodium citrate provides a composition that is highly stable and maintained in a clear solution without precipitation during storage.

5 cl, 1 dwg, 12 tbl, 16 ex