FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to pharmacy. The composition comprises an inner phase and an outer layer. The inner layer is composed of coated trimetazidine dihydrochloride in a neutral nucleus and hydroxypropylmethylcellulose. The outer layer comprises ethyl cellulose, acetyl tributyl citrate, and talc. These components are contained in the following amounts: trimetazidine dihydrochloride - 80 mg, neutral core - 36.677 mg hydroxypropyl methylcellulose - 6.40 mg, acetyl tributyl citrate - 1.2 mg ethylcellulose - 8 mg, talc - 12 mg. The invention provides a composition with prolonged trimetazidine release for over 24 hours with therapeutic concentration levels in blood maintained for 24 hours.
EFFECT: pharmaceutical composition is used for prolonged trimetazidine release.
3 cl, 5 dwg, 3 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MATRIX TABLET WITH BASIS FOR TRIMETAZIDINE DIHYDROCHLORIDE RELEASE, WAY OF ITS RECEPTION AND WAY OF TREATMENT | 2007 |
|
RU2362548C1 |
| PROLONGED PHARMACEUTICAL COMPOSITION DRUG FORM AND METHOD OF ITS PRODUCTION (VERSIONS) | 2009 |
|
RU2435584C2 |
| FORM OF PROLONGED VENLAFAXINE HYDROCHLORIDE LIBERATION | 2004 |
|
RU2340331C2 |
| MODIFIED RELEASE DOSAGE FORM OF TRIMETAZIDINE DIHYDROCHLORIDE | 2009 |
|
RU2412706C1 |
| SYSTEMS OF MEDICATION DELIVERY, INCLUDING SOLID SOLUTIONS OF WEAK-BASE MEDICATIONS | 2007 |
|
RU2434630C2 |
| SYSTEMS OF MEDICATION DELIVERY, CONTAINING WEAK-BASE MEDICATIONS AND ORGANIC ACIDS | 2007 |
|
RU2428176C2 |
| PHARMACEUTICAL COMPOSITION FOR SUSTAINED-RELEASE OF ACTIVE SUBSTANCES (VARIANTS) AND METHOD OF ITS PREPARING (VARIANTS) | 1998 |
|
RU2179017C2 |
| MODIFIED RELEASE DOSAGE FORM OF TRIMETHAZIDIN AND METHOD FOR PREPARING THEREOF (VERSIONS) | 2008 |
|
RU2410097C2 |
| DRUG OF SUSTAINED-RELEASE ACTIVE SUBSTANCE | 1994 |
|
RU2138253C1 |
| COMPOSITION FOR TREATING DISTURBED INNERVATION (VERSIONS) | 2013 |
|
RU2536269C1 |
