APPLICATION OF RECOMBINANT STRAIN OF BACILLUS SUBTILIS EO-11 RNCIM B-11978 AS THE PRODUCT OF SUBTITLISIN-LIKE PROTEINASE, SUBSTANCES WITH THROMBOLYTIC AND ANTICOAGULANT PROPERTIES Russian patent published in 2017 - IPC A61K38/48 A61P7/02 

Abstract RU 2622006 C2

FIELD: biotechnology.

SUBSTANCE: invention can be used for lysis (dissolution) of blood clots formed in the blood vessels (thrombus) that disrupt normal blood circulation and threaten life, and prevention of blood clots formation. This is achieved by using the product of vital activity of recombinant strain Bacillus subtilis EO-11 RNCIM B-11978 - subtilisin-like proteinase - a substance with thrombolytic and anticoagulant properties.

EFFECT: increasing the effectiveness of thrombus lysis, accelerating the process of thrombolysis without adverse side effects, preventing thrombus formation in the circulatory system of organisms, increasing the effectiveness and quality of treatment.

3 cl, 3 dwg

Similar patents RU2622006C2

Title Year Author Number
APPLICATION OF BACILLUS SUBTILIS TV 06 RECOMBINANT STRAINS AS GLUTAMYL PRODUCERS, SUBSTANCE WITH THROMBOLYTIC AND ANTICOAGULANT PROPERTIES 2015
  • Danilova Yuliya Vasilevna
  • Balaban Nelli Pavlovna
  • Sharipova Margarita Rashidovna
  • Mardanova Ajslu Mirkasymovna
  • Rudenskaya Galina Nikolaevna
  • Shamsutdinov Talgat Rakhimzyanovich
  • Lyutova Lyudmila Vasilevna
RU2611378C2
METHOD FOR IMMOBILIZING AN ENZYME, SUBTILISIN-LIKE PROTEINASE, PRODUCED BY A BACTERIUM STRAIN OF THE GENUS BACILLUS OF THE SPECIES BACILLUS SP_ 7P/3-19, ON THE INSTRUMENT 2017
  • Danilova Yuliya Vasilevna
  • Zamaleeva Alsu Ilgizovna
  • Fakhrullin Ravil Faridovich
  • Sharipova Margarita Rashidovna
  • Tojmentseva Anna Aleksandrovna
  • Mikhajlova Ekaterina Olegovna
RU2663128C1
METHOD OF PRODUCTION OF PLASMINOGEN ACTIVATOR 2007
  • Isaev Vjacheslav Artashesovich
  • Semenova Svetlana Aleksandrovna
  • Ljutova Ljudmila Vasil'Evna
  • Rudenskaja Galina Nikolaevna
  • Medvedeva Elena Aleksandrovna
RU2346983C1
METHOD OF PRODUCING ANTICOAGULATIVE COLLAGENASE INHIBITOR FROM KING CRAB HEPATOPANCREAS 2009
  • Isaev Vjacheslav Artashesovich
  • Rudenskaja Galina Nikolaevna
  • Rudenskaja Julija Andreevna
  • Ljutova Ljudmila Vasil'Evna
  • Balashova Marija Viktorovna
RU2403284C1
IMMOBILISED BACILLUS LICHENIFORMIS BACTERIA PRODUCED SUBTILISIN SHOWING THROMBOLYTIC AND ANTICOAGULANT PROPERTIES 2008
  • Bekarev Andrej Aleksandrovich
  • Artamonov Andrej Vladimirovich
  • Vereshchagin Evgenij Ivanovich
RU2416643C2
STRAIN OF BACTERIA BACILLUS PUMILUS MK-10 WITH LOW PROTEOLYTIC ACTIVITY AND ITS APPLICATION 2012
  • Sharipova Margarita Rashidovna
  • Balaban Nelli Pavlovna
  • Rizvanov Al'Bert Anatol'Evich
  • Mardanova Ajslu Mirkasymovna
  • Karimova Madina Rafaehlevna
  • Shagimardanova Elena Il'Jasovna
  • Tojmentseva Anna Aleksandrovna
  • Chuluntsehtsehg Njamsurehn
RU2510821C1
METHOD OF PRODUCTION OF RECOMBINANT STAPHYLOKINASE IN REGULATING LEVEL OF OXYGEN 2008
  • Radzhamokhan Govindan
  • Dakhija Monika
  • Patkhania Randzhana
  • Dikshit Kanak Lata
RU2486249C2
METHOD OF PRODUCING RECOMBINANT STAPHYLOKINASE WITH REGULATION OF OXYGEN LEVEL 2004
  • Radzhamokhan Govindan
  • Dakhija Monika
  • Patkhania Randzhana
  • Dikshit Kanak Lata
RU2373281C2
STRAIN OF BACTERIA BACILLUS PUMILUS 2A-5 WITH LOW PROTEOLYTIC ACTIVITY, INCREASED PHOSPHATASE ACTIVITY, METHOD OF ITS OBTAINING AND APPLICATION 2012
  • Sharipova Margarita Rashidovna
  • Balaban Nelli Pavlovna
  • Mardanova Ajslu Mirkasymovna
  • Akhmetova Alina Il'Dusovna
  • Mukhametzjanova Alija Damirovna
  • Shagimardanova Elena Il'Jasovna
  • Tojmentseva Anna Aleksandrovna
  • Chuluntsehtsehg Njamsurehn
RU2511416C1
STRAIN SAROCLADIUM STRICTUM - PRODUCER OF FIBRINOLYTIC ENZYMES WITH PLASMINOGEN ACTIVATING ACTIVITY 2019
  • Kornienko Elena Igorevna
  • Osmolovskij Aleksandr Andreevich
  • Sharkova Tamara Sergeevna
  • Nalobin Denis Sergeevich
  • Kurakov Aleksandr Vasilevich
RU2728456C1

RU 2 622 006 C2

Authors

Danilova Yuliya Vasilevna

Balaban Nelli Pavlovna

Sharipova Margarita Rashidovna

Mardanova Ajslu Mirkasymovna

Mikhajlova Ekaterina Olegovna

Rudenskaya Galina Nikolaevna

Lyutova Lyudmila Vasilevna

Dates

2017-06-08Published

2015-06-15Filed