FIELD: medicine.
SUBSTANCE: offered is subtilisin immobilised on a water-soluble pharmacologically acceptable polymer and produced of Bacillus licheniformis bacteria by deep fermentation. The immobilisation is enabled by exposing an aqueous solution containing subtilisin and the pharmacologically acceptable polymer to ionising radiation. The polymer is specified in a group: polyethylene oxide, polyvinylpyrrolidone, polyacrylimide, Pluronic, dextrane. Before the exposure, the reaction mixture is frozen to (-20) - (-140)°C.
EFFECT: immobilised subtilisin exhibits anticoagulant and thrombolytic properties and has a less evident toxic effect.
4 cl, 9 tbl, 3 ex
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