PILL WITH ISONIAZID AND OFLOXACIN FOR TUBERCULOSIS TREATMENT Russian patent published in 2017 - IPC A61K31/4409 A61K31/7036 A61K9/28 A61P31/06 

FIELD: pharmacology.

SUBSTANCE: proposed pill comprises isoniazid and ofloxacin as active agents, a mixture of milk sugar, potato starch 1500 and crospovidone Polyplasdone as auxiliary agents for core cladding at the ratio of 2:1:1; 7% aqueous solution of potato starch as a humidifier 1; 3% aqueous solution of povidone (Plasdone C) 2 as a humidifier 2; alcohol solution containing 5 wt % of acetylphthalylcellulose and 2 wt % of Tween-80 as a acido-resistant coating - humidifier 3; a mixture of 64% sugar syrup solution and 1.5% aqueous solution of kollidon 25 at the ratio of 5:1 as a humidifier 4 at a certain ratio of the components.

EFFECT: use of the invention ensures preparation of a new domestically produced drug in the form of a pill comprising isoniazid and ofloxacin having antiphthisic effect, with release of active agents within 1-2 hours.

2 cl, 2 dwg, 4 ex