Show metadata Hide metadata

(19)

(11)

2 633 638

(13)

(51)

IPC

A61K38/16(2006-01-01)

A61K31/40(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2014134923, 2013-02-01

(24)

Start date

2013-02-01

(22)

Actual filing date

2013-02-01

(45)

Published

2017-10-16

(72)

Inventor

Bkhatt Rupal S.Kumar RavindraMajer Dzhejms V.Pirsoll RobertSherman MettyuSolban Nikolas

(73)

Holder

Akseleron Farma Ink.Bet Izrail Dikoness Medikal Sentr

ALK1 ANTAGONISTS AND THEIR APPLICATION IN THE TREATMENT OF KIDNEY-CELLULAR CARCINOMA Russian patent published in 2017 - IPC A61K38/16 A61K31/40 A61P35/00

Abstract RU 2633638 C2

FIELD: medicine.

SUBSTANCE: invention can be used to treat renal cell carcinoma (RCC). The method of the invention comprises administering to a mammal with RCC an effective amount of sunitinib and an ALK1 polypeptide comprising a ligand-binding portion of the extracellular domain of ALK1.

EFFECT: use of the invention can slow the growth of the tumor and increase the activity of sunitinib.

10 cl, 20 dwg, 15 ex

Similar patents RU2633638C2

Title	Year	Author	Number
ANTAGONISTS OF ALK1 RECEPTOR AND LIGANDS AND THEIR APPLICATION	2007	Grinberg, Asja Nopf, Dzhon Kumar, Ravindra Pirsall, Robert, Skott Sikhra, Dzhasbir	RU2559532C2
NOVEL HYBRID ACTRIIB LIGAND TRAP PROTEINS FOR TREATING DISEASES ASSOCIATED WITH MUSCULAR ATROPHY	2016	Han Hq Zhou Xiaolan	RU2733492C2
THERAPEUTIC APPLICATION OF BONE MORPHOGENETIC PROTEINS	2015	Morrell Nikolas V Li Vej Apton Pol D	RU2733318C2
MOLECULES WHICH BIND LIGANDS AND USE THEREOF	2014	Gerometta Michael Adams Timothy	RU2699007C2
TARGETED/IMMUNOMODULATING FUSION PROTEINS AND METHODS FOR THEIR OBTAINING	2013	Govindappa Nagaradzh Sastru Kedarnat Soares Mariya Melina	RU2636342C2
COMPOSITIONS AND METHODS OF PULMONARY HYPERTENSION TREATMENT	2017	Kumar, Ravindra Knopf, John	RU2748278C2
METHODS OF TREATING CANCER USING PD-1 AXIS BINDING AND VEGF ANTAGONISTS	2013	Maecker Heather Irving Bryan	RU2689760C2
METHOD OF TREATING DISEASES BY VEGF ANTAGONISTS	2006	Shtal' Nejl Jankopulos Dzhordzh D. Ferfajn Ehrik Sedarbaum Dzhess M.	RU2414924C2
FGF-R-Fc FUSED PROTEIN AND USE THEREOF	2012	Fan Tszjan'Min' Li Dun	RU2560573C2
ANTIANGIOGENIC INDUCER FUSION PROTEIN AND USING IT	2012	Fan Tszjan'Min' Li Dun	RU2560589C2

RU 2 633 638 C2

Authors

Bkhatt Rupal S.

Kumar Ravindra

Majer Dzhejms V.

Pirsoll Robert

Sherman Mettyu

Solban Nikolas

Dates

2017-10-16—Published

2013-02-01—Filed