ANTAGONISTS OF ALK1 RECEPTOR AND LIGANDS AND THEIR APPLICATION Russian patent published in 2015 - IPC C07K14/71 C07K19/00 A61K38/16 A61P35/00 

Abstract RU 2559532 C2

FIELD: medicine.

SUBSTANCE: claimed invention relates to field of biotechnology. Claimed method of treating tumour in mammal, including introduction of efficient quantity of fusion protein ALK1-Fc, where fusion protein ALK1-Fc contains extracellular domain (ECD) similar to activin receptor-like kinase I (ALK1 or ACVRL1), fused at C-end with Fc-region of immunoglobulin.

EFFECT: fusion protein ALK1-Fc in accordance with invention is capable of binding GDF5, GDF7 and BMP9, providing inhibition of development of blood vessels.

16 cl, 10 dwg, 8 ex

Similar patents RU2559532C2

Title Year Author Number
ALK1 ANTAGONISTS AND THEIR APPLICATION IN THE TREATMENT OF KIDNEY-CELLULAR CARCINOMA 2013
  • Bkhatt Rupal S.
  • Kumar Ravindra
  • Majer Dzhejms V.
  • Pirsoll Robert
  • Sherman Mettyu
  • Solban Nikolas
RU2633638C2
NOVEL HYBRID ACTRIIB LIGAND TRAP PROTEINS FOR TREATING DISEASES ASSOCIATED WITH MUSCULAR ATROPHY 2016
  • Han Hq
  • Zhou Xiaolan
RU2733492C2
THERAPEUTIC APPLICATION OF BONE MORPHOGENETIC PROTEINS 2015
  • Morrell Nikolas V
  • Li Vej
  • Apton Pol D
RU2733318C2
MOLECULES WHICH BIND LIGANDS AND USE THEREOF 2014
  • Gerometta Michael
  • Adams Timothy
RU2699007C2
COMPOSITIONS AND METHODS OF PULMONARY HYPERTENSION TREATMENT 2017
  • Kumar, Ravindra
  • Knopf, John
RU2748278C2
TARGETED/IMMUNOMODULATING FUSION PROTEINS AND METHODS FOR THEIR OBTAINING 2013
  • Govindappa Nagaradzh
  • Sastru Kedarnat
  • Soares Mariya Melina
RU2636342C2
FUSED PROTEINS CONTAINING PDGF AND VEGF BINDING PARTS, AND METHODS FOR USE THEREOF 2014
  • Pechan Piter
  • Ardinger Dzheffri
  • Rubin Khillard
  • Uodsvort Semyuel
  • Skaria Abrakham
RU2692652C2
POLYPEPTIDES AND POLYNUCLEOTIDES AND THEIR USE FOR TREATMENT OF IMMUNE DISORDERS AND CANCER 2012
  • Toporik Amir
  • Novik Amit
  • Shemesh Ronen
RU2623161C2
ANTI-EphB4 ANTIBODIES AND METHODS OF USING SAID ANTIBODIES 2007
  • Vu Jan
  • Jan' Minkhong
RU2450020C2
TGF-BETA RECEPTOR ECTODOMAIN FUNCTIONS AND THEIR USE 2018
  • Lenferink Anne E.G.
  • Zwaagstra John C.
  • Sulea Traian
  • O'Connor-Mccourt Maureen D.
RU2797464C2

RU 2 559 532 C2

Authors

Grinberg, Asja

Nopf, Dzhon

Kumar, Ravindra

Pirsall, Robert, Skott

Sikhra, Dzhasbir

Dates

2015-08-10Published

2007-11-02Filed