ANTAGONISTS OF ALK1 RECEPTOR AND LIGANDS AND THEIR APPLICATION Russian patent published in 2015 - IPC C07K14/71 C07K19/00 A61K38/16 A61P35/00 

Abstract RU 2559532 C2

FIELD: medicine.

SUBSTANCE: claimed invention relates to field of biotechnology. Claimed method of treating tumour in mammal, including introduction of efficient quantity of fusion protein ALK1-Fc, where fusion protein ALK1-Fc contains extracellular domain (ECD) similar to activin receptor-like kinase I (ALK1 or ACVRL1), fused at C-end with Fc-region of immunoglobulin.

EFFECT: fusion protein ALK1-Fc in accordance with invention is capable of binding GDF5, GDF7 and BMP9, providing inhibition of development of blood vessels.

16 cl, 10 dwg, 8 ex

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RU 2 559 532 C2

Authors

Grinberg, Asja

Nopf, Dzhon

Kumar, Ravindra

Pirsall, Robert, Skott

Sikhra, Dzhasbir

Dates

2015-08-10Published

2007-11-02Filed