FIELD: medicine.
SUBSTANCE: living three-dimensional engineered tissue or organ are proposed comprising multiple interlocked layers and free from preformed scaffold. At that, they have at least one component obtained by bioprinting performed by bioink extrusion on a biocompatible surface. Bioink is a solid or semi-solid composition containing living cells. At least one layer of the engineering tissue or organ comprises muscle cells, wherein the engineering tissue or organ is not a vascular tube. It is also proposed to use the said tissue or organ for implantation to a spinal, and method of their preparation.
EFFECT: creation of cell layers with a certain density sufficient to create an integrated tissue without scaffold, fit for implantation.
56 cl, 1 tbl, 16 ex, 13 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| DEVICES, SYSTEMS AND METHODS OF MAKING FABRIC | 2011 |
|
RU2560393C2 |
| ARTIFICIAL LIVER TISSUES, ARTIFICIAL TISSUE MATRICES AND METHODS FOR THEIR PREPARATION | 2014 |
|
RU2625016C2 |
| MULTILAYERED VASCULAR TUBES | 2011 |
|
RU2522966C2 |
| METHOD FOR CREATING TISSUE-ENGINEERING STRUCTURES BY BIOPRINTING WITH BIOINK FOR CARTILAGE TISSUE REGENERATION UNDER BODY CONDITIONS | 2021 |
|
RU2770558C2 |
| METHOD FOR OBTAINING BIOINK THAT PROVIDES A HIGH LEVEL OF POROSITY IN TISSUE ENGINEERIED STRUCTURES | 2021 |
|
RU2772734C2 |
| METHOD FOR CREATING A PREPOLYMERIZATION MORPHOGENETIC MATRIX | 2022 |
|
RU2791073C1 |
| ROBOTIC MEDICAL SYSTEM AND MANIPULATOR FOR 3D BIOPRINTING FOR FULL-THICKNESS SKIN DEFECT CLOSURE | 2023 |
|
RU2814949C1 |
| METHODS FOR PRODUCING TISSUES | 2013 |
|
RU2733838C2 |
| ARTIFICIAL DURA MATER AND METHOD OF ITS PRODUCTION | 2010 |
|
RU2491961C2 |
| METHOD OF RESTORING DEFECT AND ARTICULAR CARTILAGE DAMAGE | 2015 |
|
RU2578369C1 |
