FIELD: pharmacology.
SUBSTANCE: application of rac-n-{4-[(2-ethoxy-3-octadecyloxy)propyl] oxycarbonylbutyl}-n-methyl-imidazoline iodide based on the identified activity as neoplastic cells Ins-R, MET, Src and Pim-1 protein kinases inhibitor.
EFFECT: ability of the said compound to inhibit all the said protein kinases that mediate the carcinogenesis of those types of tumour cells in which they are actively expressed, unlike edelphosphine.
1 tbl, 1 dwg, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| Rac-N,N-DIMETHYL-N-[2-(5-N',N'-DIMETHYLAMINONAPHTHALENE-1-SULFONYLOXY)ETHYL]-N-{4-[(2-METHOXY-3-OCTADECYLOXY)PROP-1-YLOXYCARBONYL]BUTYL}AMMONIUMIODIDE | 2008 |
|
RU2382765C1 |
| LIPOPHILIC POLYAMINES WITH ANTITUMOUR ACTIVITY | 2016 |
|
RU2618393C1 |
| PIM1-KINASE INHIBITOR 6-[(4-METHYL-I-1-PIPERAZINYL)METHYL]-INDOLO[1',7':1,2,3]PYRROLO[3',4':6,7]AZEPINO[4,5-b]INDOLE-1,3(2H, 10H)-DIONE, METHOD FOR PREPARING AND USING IT | 2011 |
|
RU2466132C1 |
| TEST SYSTEM FOR HUMAN PROTEIN KINASE GSK3β INHIBITOR SCREENING | 2012 |
|
RU2528059C2 |
| PHOSPHORUS CONTAINING COMPOUNDS AS PROTEIN KINASE INHIBITORS | 2012 |
|
RU2598849C2 |
| METHOD OF TREATING ABNORMAL CELL EXPANSION | 2006 |
|
RU2384331C2 |
| WAYS AND PHARMACOLOGICAL COMPOSITIONS FOR HEALING OF WOUNDS | 2004 |
|
RU2359694C2 |
| METHODS AND PHARMACOLOGICAL COMPOSITIONS FOR WOUND HEALING | 2004 |
|
RU2491952C2 |
| 4-(1-(4-(4-METHOXYPHENYLTHIO)-2,5-DIOXO-2,5-DIHYDRO-1H-PYRRO-3-YL)-1H-INDOL-3-YL)BUTYLCARBAMIMIDOTHIOATE AND METHOD FOR USING IT | 2009 |
|
RU2441000C2 |
| METHOD FOR IDENTIFICATION AND/OR VERIFICATION OF INHIBITORS OF RECEPTOR TYROSINE KINASES | 2003 |
|
RU2366716C2 |
