NICOTINE PHARMACEUTICAL FORM Russian patent published in 2017 - IPC A61K9/00 A61K31/465 A61K47/02 A61K47/36 

FIELD: pharmacology.

SUBSTANCE: nicotine-containing mucoadhesive film and method of producing nicotine-containing mucoadhesive film by preparing an aqueous solution with pH value from 9.5 to 13 are described, wherein the mentioned solution comprises (i) a nicotine salt, (ii) an alkaline pH-adjusting agent, and (iii) a film-forming agent containing monovalent cation alginate or a mixture of monovalent cations alginates, wherein the film-forming agent has an average content of guluronate (G) from 50 to 85 wt %, average content of mannuronate (M) from 15 to 50 wt %, average molecular weight from 30,000 to 90,000 g/mol, and its 10% aqueous solution has a viscosity of 100-1000 mPa/s at 20°C, measured at a shear rate of 20 r/min on a Brookfield viscometer with spindle 2; applying of the solution onto a solid surface; and drying of the solution on the mentioned surface.

EFFECT: method enables to maintain the nicotine content while storing.

24 cl, 1 dwg, 6 tbl, ex 3