METHODS FOR PATHOLOGICAL CHANGES DETECTION IN ORGAN OR SYSTEM OF ORGANS Russian patent published in 2017 - IPC C12Q1/68 A61K48/00 

FIELD: biotechnology.

SUBSTANCE: methods for pathology detection in an organ or organ system, a method for identification of a compound suitable for slowing the progression or treatment of a pathology of an organ system, and a method for determination of compound or environmental factor toxicity for a system of organs. Methods for pathology detection in organs or organ systems include measurement of microRNA, with which an organ or an organ system is enriched, measurement of normalizing microRNA level in the same sample of biological fluid, microRNA levels ratio calculation and microRNA levels ratio comparison with the appropriate control ratio. At that, in the method for compound identification, measurement of the microRNA level and the normalizing microRNA level is performed before and after administration of the test compound for comparison. In the method for compound or environmental factor toxicity determination, microRNA is measured and the level of the normalizing microRNA is measured also before and after exposure to the said compound or factor to compare them.

EFFECT: inventions provide early detection of pathological changes in an organ system or in a particular organ of the individual.

58 cl, 148 dwg, 11 tbl, 8 ex