PRODUCTION OF IMMUNOGLOBULINS WITH REDUCED THROMBOGENIC AGENT CONTENT, AND IMMUNOGLOBULIN COMPOSITION Russian patent published in 2017 - IPC C07K1/18 C07K16/06 A61K39/395 

FIELD: biotechnology.

SUBSTANCE: methods include plasma fractionation according to Cohn, and/or Kistler-Nitschmann to obtain an immunoglobulin-containing solution. Then, the immunoglobulin solution is contacted with a cation exchanger equilibrated at a pH of 3.8 to 5.3, for factor XI, factor XIa, and kallikrein binding, and with an anion exchanger equilibrated at a pH of 7 to 8.2, for prekallikrein binding. Then, the unbound immunoglobulin-containing fractions are collected. The resulting immunoglobulin composition comprises 4-10% of the total protein and is suitable for treating patients with immunodeficiency, inflammatory disease, autoimmune disease, or acute infection.

EFFECT: invention maximizes thrombogenic agents factor XI, factor XIa, kallikrein and prekallikrein removal from the immunoglobulin solution using a cation exchanger in a very narrow range of pH values, while maintaining a constant level of immunoglobulin in the solution.

49 cl, 16 tbl, 14 ex