COMPOSITIONS WITH CONTROLLED RELEASE AND METHODS OF THEIR USE Russian patent published in 2017 - IPC A61K31/546 A61K31/542 A61K47/04 A61K47/14 A61K47/26 A61K47/44 A61K9/10 A61J3/00 A61P31/04 

FIELD: veterinary medicine.

SUBSTANCE: composition contains the therapeutically effective amount of at least one active substance and the base, containing colloidal silicon dioxide in the concentration from 0.1 upto 5% by weight, at least one oil and at least one surface active agent in the concentration from 0.01 upto 10% by weight. The active agent is chosen from the group of antibiotics, containing betalactams, penicillins, cephalosporins, aminoglycosides, quinolones, sulfonamides, tetracyclines, macrolides and combinations thereof. The oil is selected from the group, consisting of triglycerides, light vaseline oil, ethyl oleate, sesame oil and peanut oil. The colloidal silicon dioxide is dispersed in the oil in the composition according to the invention. The viscosity of the composition is less than 1000 mPas at the shear rate of 100 1/s and at the temperature of 20°C. Also described the composition manufacturing method and application for treating or preventing measures of mastitis at the animal which need it.

EFFECT: according to the invention the composition provides the controlled release of the active agents from the composition with low viscosity.

24 cl, 16 dwg, ex 18