METHOD FOR GETTING SURGICAL BARRIER MATERIAL BASED ON POLYSACCHARIDES Russian patent published in 2017 - IPC A61L31/10 A61L31/16 A61P41/00 

FIELD: biotechnology.

SUBSTANCE: to get the barrier material using apple pectin and chitosan, the last preferably with 38-100% deacetylation degree and molecular weight 25-230 kDa. According to the method, apple pectin is dissolved in water, calcium chloride or chitosan with addition of calcium chloride is dissolved in 0.25% aqueous solution of acetic acid, the resulting solution is frozen at minus 18±1°C, then layer the apple pectin solution to it. Mass ratio of pectin and chitosan is 3:1. The frozen solution is slowly thawed for 4-6 hours at a temperature of 15-22°C. The formed surgical barrier material is freeze-dried and then sterilized by UV irradiation.

EFFECT: surgical barrier material in the form of cryogel has biocompatible properties, a period of biodegradation not exceeding 24 hours, and allows effective prevention of adhesions formation in the experiment.

2 cl, 1 dwg, 2 tbl, 5 ex