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2 628 456

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IPC

C07D239/545(2006-01-01)

A61K31/513(2006-01-01)

A61P31/14(2006-01-01)

(21) (22)

Application

2016125942, 2016-06-29

(24)

Start date

2016-06-29

(22)

Actual filing date

2016-06-29

(45)

Published

2017-08-17

(72)

Inventor

Novikov Mikhail StanislavovichNikitenko Natalya AnatolevnaOzerov Aleksandr AleksandrovichGureeva Elena SergeevnaPrasolov Vladimir SergeevichProkofeva Mariya MikhajlovnaDzharullaeva Alina ShakhmirovnaTukhvatulin Amir IldarovichLogunov Denis Yurevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Institut Molekulyarnoj Biologii Im. V.A. Engelgardta Rossijskoj Akademii Nauk Ran)

NEW PYRIMIDINE INHIBITORS OF HUMAN ADENOVIRUS REPLICATION Russian patent published in 2017 - IPC C07D239/545 A61K31/513 A61P31/14

Abstract RU 2628456 C1

FIELD: pharmacology.

SUBSTANCE: invention relates to new 5-aminouracil derivatives containing4-(phenoxy) benzyl or ω-(phenoxy)alkyl substituent in the N¹ position, corresponding to the general structural formula (I). Compounds represent a new class of anti-adenoviral agents of a non-nucleoside nature. In the general formula (I), X = CH or N; Y=(CH₂)₂, (CH₂)₃, (CH₂)₄orC₆H₄; R1= H, R2= C₆H or 3,5-Cl₂C₆H₃; R₁+R₂= morpholino;R₃=H, F or Cl.

EFFECT: compounds have a selective antiviral effect against human adenoviruses and can be used for treatment of adenoviral infections.

1 dwg, 3 tbl, 11 ex

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RU 2 628 456 C1

Authors

Novikov Mikhail Stanislavovich

Nikitenko Natalya Anatolevna

Ozerov Aleksandr Aleksandrovich

Gureeva Elena Sergeevna

Prasolov Vladimir Sergeevich

Prokofeva Mariya Mikhajlovna

Dzharullaeva Alina Shakhmirovna

Tukhvatulin Amir Ildarovich

Logunov Denis Yurevich

Dates

2017-08-17—Published

2016-06-29—Filed