FIELD: chemistry.
SUBSTANCE: invention relates to novel N-arylacetamide derivatives of 2-thiouracil of the general formula indicated below having an antiviral effect against human adenoviruses. In general formula
X = bond or CH2; R1=H, CH3, CH2C6H5 or (CH2)2OC6H5; R2=H, CH3, C2H5, C3H7, CH(CH3)2, CH2OCH2(p-CH3C6H4), CH2OCH(C6H5)2, CH2O(CH2)2OC6H5 or CH2N(CH3)C6H5; R1+R2=CH=CH-CH=CH; R3=H or CH3; R4=H, OC4H9, C6H5, CH2C6H5, C(O)C6H5 or OAr; Ar=C6H5, C6H4R5 or C6H3(R5)2; R5=o-, m-, p-Cl, Br, CH3, C(CH3)3 or 1-C10H7.
EFFECT: invention has an antiviral effect against human adenoviruses.
1 cl, 1 dwg, 3 tbl, 39 ex
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