SUBSTITUTED BENZENE COMPOUNDS Russian patent published in 2017 - IPC C07D213/64 C07D401/12 C07D401/14 C07D407/12 C07D409/12 C07D413/12 C07D413/14 C07D491/10 C07D491/113 A61K31/4427 A61P35/00 

FIELD: pharmacology.

SUBSTANCE: invention relates to compounds of formula (Ie) or pharmaceutically acceptable salts thereof: where Z is NR₇R₈ or S(O)aR₇, where a is 0; R₁ is H or C₁-C₆ alkyl optionally substituted with one or more substituents selected from hydroxyl, C₁-C₆ alkoxy; Each of R₂ and R₄ is independently -Q₁-T₁, wherein Q₁ is a bond or a C₁-C₃ alkyl linker optionally substituted with one or more substituents selected from halogen and hydroxyl, and T₁ is H, C₁-C₃ alkyl; R₃ is H or halogen; R₅ is H or C₁-C₆ alkyl; R₆ is H, halogen, -C(O)NR_aR_b or R_S2, where R_S2 is C₁-C₆ alkyl or 4-12 membered heterocycloalkyl containing from 0 to 3 heteroatoms in the ring selected from O, N or S, and Wherein each of R_a and R_b is independently H, C₁-C₆ alkyl or R_a and R_b together with the N atom to which they are attached form a 4-12 membered heterocycloalkyl ring containing 0 or 1 additional heteroatom selected from O, N or S; R₇ is -Q₄-T₄, wherein Q₄ is a bond or a C₁-C₄ alkyl linker and T₄ is H, C₁-C₆ alkyl, C₃-C₈ cycloalkyl, C(O)-C1-C₆ alkyl or 4-14 membered heterocycloalkyl, Containing 1 to 3 ring heteroatoms selected from O, N or S, each of which is optionally substituted with one or more -Q₅-T₅, wherein Q₅ is a bond, C(O), C(O) NR_k, NR_kC(O) or a C₁-C₃ alkyl linker, wherein R_k is H or C₁-C₆ alkyl, and T₅ is H, C₁-C₆ alkyl; R₈ is H, C₁-C₆ alkyl optionally substituted with halogen or C₁-C₆ alkoxy, C₂-C₆ alkenyl, C₃-C₈ cycloalkyl or 4- to 7-membered heterocycloalkyl containing 1-3 heteroatoms in the ring selected from O, N or S; or R₇ and R₈ together with the N atom to which they are attached form a 4-12 membered heterocycloalkyl ring containing 0-2 additional heteroatoms selected from O, S or N and a 4-12 membered heterocycloalkyl ring that forms R₇ and R₈ is optionally substituted with one or more -Q₆-T₆, wherein Q₆ is a bond or a C₁-C₃ alkyl linker and T₆ is H, halogen, C₁-C₆ alkyl; and R₁₂ is halogen, C₁-C₆ alkoxyl, C₂-C₆ alkenyl or C₁-C₆ alkyl optionally substituted with halogen.

EFFECT: compounds are used to treat cancer.

24 cl, 4 tbl, 47 ex