AMID DERIVATIVES OF N-CARBAMIDE-SUBSTITUTED AMINO ACIDS AS MODULATORS OF FORMYLPEPTIDE RECEPTOR-1 (FPRL-1) Russian patent published in 2017 - IPC C07C275/30 C07C317/42 C07C317/50 C07C323/44 C07C323/60 C07D209/20 C07D233/64 C07K5/06 A61K31/17 A61K31/197 A61K31/216 A61K31/4045 A61K31/417 

FIELD: chemistry.

SUBSTANCE: invention relates to a compoundd represented by the formula

,

its enantiomers, diastereoisomers or pharmaceutically acceptable salts, which have modulatory activity against N-formylpeptide receptor-1 (FPRL-1). In formula II, a is 1, b is 0 or a is 1, b is 1; R¹ is -OH; R² is C₁-₈ Alkyl, optionally substituted by C₆-₁₀ aryl, amide or heterocycle, wherein the heterocycle is a 3 to 10-membered aromatic ring which contains at least one heteroatom selected from nitrogen, wherein one methylene group in the alkyl can be replaced by sulfur or sulphonyl; R³ is hydrogen or halogen; R⁴ is hydrogen; R⁵ is a halogen, -CF₃ Or -S (O)_nR¹⁴; N is 0, 1 or 2; R⁶ is hydrogen; R⁷ is hydrogen or halogen; R⁸ is hydrogen or C_1-8 Alkyl; ^R9 is hydrogen, C_1-8 Alkyl, Optionally substituted with a hydroxyl group, or C_6-10 aryl; R¹⁰ is hydrogen, C_1-8 alkyl optionally substituted with a hydroxyl group, or C_6-10 aryl; R^9a is hydrogen or C_1-8 alkyl optionally substituted with a hydroxyl group; R^10a is hydrogen or C_1-8 alkyl optionally substituted with a hydroxyl group; R¹⁴ is CF₃ or C_1-8 alkyl.

EFFECT: increased activity of derivatives.

12 cl, 5 tbl, 4 ex