PHENYLCARBAMATE DERIVATIVES AS FORMYL PEPTIDE RECEPTOR MODULATORS Russian patent published in 2019 - IPC C07C271/28 C07C305/06 C07C305/12 C07C307/06 C07C309/15 C07C309/19 C07D257/04 C07F9/38 C07F9/40 A61K31/27 A61K31/41 A61K31/66 A61P29/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula I, enantiomers thereof or pharmaceutically acceptable salts thereof, having the action of a modulator of N-formylpeptide receptor 2 (FPR2). In formula IR¹ is halogen, fluorinated C_1-8 alkyl or perfluorinated C_1-8 alkyl; R² is H; R³ is H; R⁴ is H; R⁵ is H; R⁶ is H, C_1-8 alkyl or -CH₂C_6-10aryl; R^6a is H; R⁷ is H or C_1-8 alkyl; R⁸ is H; R⁹ is H; R¹⁰ is -(CH₂)_nOR¹⁶, -(CH₂)_nS (O)₂OH, -(CH₂)_nC(O)R¹⁷, -(CH₂)_nOS (O)₂OH, -(CH₂)_nNR¹⁸R¹⁹, -(CH₂)_nP(O)(OC_1-6 alkyl)₂ or heterocycle, where the heterocycle is aromatic monocyclic 5-6-member ring containing at least one heteroatom selected from nitrogen; R¹⁶ is H or -C(O)(C_1-8 alkyl); R¹⁷ is OH or -OC_1-8 alkyl; R¹⁸ is selected from a group consisting of H, -C(O)R¹⁷ and -S(O)₂N(C_1-8 alkyl)₂; R¹⁹ represents H and n equals 0, 1, 2, 3, 4, 5, 6, 7 or 8.

EFFECT: invention also relates to intermediate compounds used to produce compounds of formula I, a pharmaceutical composition containing compounds of formula I, and use of said compounds for treating a condition facilitated by modulating FPR2.

11 cl, 1 dwg, 4 tbl, 9 ex