FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry, namely to 2,5-dioxoimidazolidin-1-yl-3-phenylurea derivative of formula (I) or its enantiomer, diastereomer or pharmaceutically acceptable salt, where R1 is halogen or hydrogen; R2 is halogen, C1-8 alkyl, OR9, CN or SR15; R3 is hydrogen or C6-10 aryl; R4 is C1-8 alkyl,
,
,
,
,
,
C3-8 cycloalkyl or together with R5 forms a spiro-monocyclic or bicyclic carbocyclic saturated or partially unsaturated 5- to 10-membered ring; R5 is C1-8 alkyl optionally substituted with phenyl which is optionally substituted Cl, F, OH, F and OH, -(COOMe) or -COOH; furan, methylfuran, thiophene, pyridine, indole or OH; C3-8 cycloalkyl, ethylindole or together with R4 forms a spiro-monocyclic or bicyclic carbocyclic saturated or partially unsaturated 5- to 10-membered ring; R6 is halogen or hydrogen; R7 is hydrogen; R8 is halogen or hydrogen; R9 is C1-8 alkyl; R15 is C1-8 alkyl; R17 is hydrogen, C6-10 aryl or C1-8 alkyl optionally substituted with methoxyphenyl; R18 is hydrogen or C1-8 alkyl substituted OH, CO2t-Bu, COOH or CONH2; R19 is C1-8 alkyl substituted with OH; each R20 is independently selected from hydrogen or C1-8 alkyl; R21 is hydrogen; n is 1 or 2; m is 1 or 2; and including the following compounds:
and
;
with the proviso that the compound of formula I does not have the structure indicated in claim 1. Invention also relates to pharmaceutical composition based on the compound of formula I. .
EFFECT: new 2,5-dioxoimidazolidine-1-yl-3-phenylurea derivatives useful as modulators of N-formylpeptide receptor 1 (FPRL-1) have been obtained.
12 cl, 11 tbl, 17 ex
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Authors
Dates
2018-02-27—Published
2012-11-10—Filed