DERIVATIVES OF 2,5-DIOXOIMIDAZOLIDINE-1-YL-3-PHENYLUREA AS MODULATORS OF FORMYLPEEPTITIDE RECEPTOR 1 (FPRL-1) Russian patent published in 2018 - IPC C07D233/80 C07D235/02 C07D401/06 C07D403/04 C07D403/06 C07D405/06 C07D409/06 A61K31/4184 A61K31/4178 A61K31/4166 A61P29/00 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry, namely to 2,5-dioxoimidazolidin-1-yl-3-phenylurea derivative of formula (I) or its enantiomer, diastereomer or pharmaceutically acceptable salt, where R¹ is halogen or hydrogen; R² is halogen, C_1-8 alkyl, OR⁹, CN or SR¹⁵; R³ is hydrogen or C_6-10 aryl; R⁴ is C_1-8 alkyl,

, , , , ,

C_3-8 cycloalkyl or together with R⁵ forms a spiro-monocyclic or bicyclic carbocyclic saturated or partially unsaturated 5- to 10-membered ring; R⁵ is C_1-8 alkyl optionally substituted with phenyl which is optionally substituted Cl, F, OH, F and OH, -(COOMe) or -COOH; furan, methylfuran, thiophene, pyridine, indole or OH; C_3-8 cycloalkyl, ethylindole or together with R⁴ forms a spiro-monocyclic or bicyclic carbocyclic saturated or partially unsaturated 5- to 10-membered ring; R⁶ is halogen or hydrogen; R⁷ is hydrogen; R⁸ is halogen or hydrogen; R⁹ is C_1-8 alkyl; R¹⁵ is C_1-8 alkyl; R¹⁷ is hydrogen, C_6-10 aryl or C_1-8 alkyl optionally substituted with methoxyphenyl; R¹⁸ is hydrogen or C_1-8 alkyl substituted OH, CO₂t-Bu, COOH or CONH₂; R¹⁹ is C_1-8 alkyl substituted with OH; each R²⁰ is independently selected from hydrogen or C_1-8 alkyl; R²¹ is hydrogen; n is 1 or 2; m is 1 or 2; and including the following compounds:

and

;

with the proviso that the compound of formula I does not have the structure indicated in claim 1. Invention also relates to pharmaceutical composition based on the compound of formula I. .

EFFECT: new 2,5-dioxoimidazolidine-1-yl-3-phenylurea derivatives useful as modulators of N-formylpeptide receptor 1 (FPRL-1) have been obtained.

12 cl, 11 tbl, 17 ex