FIELD: pharmacology.
SUBSTANCE: invention relates to the new quaternary ammonium salts of 2-aminothiophene-3-carboxylic acid derivatives having anti-tuberculosis activity of general formula I
and formula II
where X is absent or is -CH2-, -(CH2)2-, CH3CH-, -N(R4)-; R1 is CN, C(O)OR5, C(O)NHR6; R4 are aliphatic saturated, unbranched or branched C1-C5 hydrocarbon, benzyl; R5 are aliphatic saturated, unbranched or branched C1-C5 hydrocarbon; R6 are H, aliphatic saturated, unbranched or branched C1-C5 hydrocarbons, cyclic hydrocarbons C3-C7.
EFFECT: increased efficiency.
2 cl, 2 tbl, 12 ex
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