FIELD: biotechnology.
SUBSTANCE: nutritional compositions for stimulating mucosal immune system, method of manufacturing and applying them are proposed. The composition comprises a milk or cereal product fermented with probiotic bacterium Lactobacillus paracasei (CBA L74) BCCM/LMG LMG P-24778. Alternatively, the composition comprises L. paracasei LMG P-24778 in amount of from about 1×102 CFU/g to about 1012 CFU/g of bacteria on 1 gram of dry mass and a physiologically acceptable carrier. The method of manufacturing the composition comprises combining the food product with an effective amount of Lactobacillus paracasei LMG P-24778 and incubating the mixture at a temperature and for a time sufficient for fermentation. Nutritional kits are proposed, comprising compositions based on L. paracasei LMG P-24778 or fermented milk or grain product and one or more items, selected from group consisting of a packaging material, a package insert including instructions for use, a sterile liquid, and a sterile container.
EFFECT: proposed compositions of the invention may be administered to a patient having gastrointestinal disorders or the risk their development, which refers to an inadequate development of immune system, infection or disease, to stimulate immunomodulatory reaction in mucosal immune system.
30 cl, 34 dwg, 20 ex
