STRAIN LACTOBACILLUS PARACASEI CNCM I-2116 (NCC 2461) ELICITING ABILITY TO PREVENT INFECTION OF EPITHELIAL CELLS INTESTINE WITH DIARRHEA-INDUCING ROTAVIRUSES AND AGENT FOR TREATMENT AND/OR PROPHYLAXIS OF DIARRHEA-ASSOCIATED DISORDERS CAUSED BY ROTAVIRUSES Russian patent published in 2005 - IPC

FIELD: biotechnology, microbiology.

SUBSTANCE: the strain Lactobacillus paracasei CNCM I-2116 (Ncc 2461) is able to attach with mammal intestine mucosa and to grow in the presence of up to 0.4% of bile acid salts and to prevent the infection of intestine epithelial cells with rotaviruses. Agent shows the content from 1 x 10⁵ to 1 x 10¹² CFU of the strain L. paracasei I-2116 (NCC 2461) and can be used for preparing an agent and foodstuff taken among milk, yogurt, cheese, dry milk, children's nutrition products or a pharmaceutical preparation taken among a liquid bacterial suspension, dry oral supplement, liquid oral supplement, dry product for feeding through a tube or liquid product for feeding through a tube. Invention provides the enhanced viability of the strain in its using and effectiveness in prevention of adhesion to intestine cells and invasion of pathogenic microorganism cells in intestine causing diarrhea. Invention can be used in food industry and medicine in prophylaxis and/or treatment of diarrhea-associated diseases.

EFFECT: valuable medicinal properties of strain and agent.

3 cl, 5 dwg, 7 ex