FIELD: pharmacology.
SUBSTANCE: at first, fullerene C60 crystals are dissolved in N-methylpyrrolidone. The resulting solution is filtered from insoluble particles through a glass fiber filter and mixed with a stabiliser solution represented by pluronic F-127 at a weight ratio of fullerene to pluronic of 5:1÷1:2, or pluronic L-121 at a weight ratio of fullerene to pluronic of 1:2. The resulting mixture is dialyzed.
EFFECT: invention allows to obtain stable aqueous fullerene dispersions containing physiological salt concentrations suitable for preparation of drugs intended for external use and intravenous administration.
8 dwg, 1 tbl, 12 ex
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Authors
Dates
2017-09-11—Published
2015-10-20—Filed