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(19)

(11)

2 630 656

(13)

(51)

IPC

C07K16/28(2006-01-01)

C12N15/13(2006-01-01)

C12N5/10(2006-01-01)

(21) (22)

Application

2014114527, 2012-09-12

(24)

Start date

2012-09-12

(22)

Actual filing date

2012-09-12

(45)

Published

2017-09-11

(72)

Inventor

Snell DenielMenrad AndreasLakorsia DzhinaShankara SrinivasTsyu KhuavejPan KlarkKebbl Bendzhamin

(73)

Holder

Dzhenzim Korporejshn

ANTIBODIES AGAINST αβTCR Russian patent published in 2017 - IPC C07K16/28 C12N15/13 C12N5/10

Abstract RU 2630656 C2

FIELD: biotechnology.

SUBSTANCE: humanized monoclonal antibody is obtained which comprises a heavy chain variable region comprising an amino acid sequence selected from SEQ ID NO: 7, 12, 13, 15 and 16, and a light chain variable region comprising the amino acid sequence SEQ ID NO: 14, and also a host cell that expresses the nucleic acid that encodes it.

EFFECT: invention effectively suppresses the T-cell-mediated response in a subject.

13 cl, 26 dwg, 2 tbl, 7 ex

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RU 2 630 656 C2

Authors

Snell Deniel

Menrad Andreas

Lakorsia Dzhina

Shankara Srinivas

Tsyu Khuavej

Pan Klark

Kebbl Bendzhamin

Dates

2017-09-11—Published

2012-09-12—Filed