FIELD: pharmacology.
SUBSTANCE: invention relates to cyclosporin-A analogs containing modifications of substituents at amino acids positions 1 and 3, according to the following Formula (I)
.
EFFECT: compounds have an affinity for cyclophilin, including cyclophilin-A, and reduced immunosuppressive activity compared to cyclosporin-A and its analogs modified only by position 1.
22 cl, 1 dwg, 5 tbl, 26 ex
| Title | Year | Author | Number |
|---|---|---|---|
| IMMUNOFYLLINE-SPECIFIC LIGANDS AS ANTIASTHMATIC AND IMMUNO-DEPRESSANT AGENTS AND METHOD OF THEIR SYNTHESIS, PHARMACEUTICALLY READY FORM, MEDICINAL AGENT AND METHOD OF ITS PREPARING | 1997 |
|
RU2172743C2 |
| 2-AMIDO-4-ARYLOXY-1-CARBONYLPYRROLIDINE DERIVATIVES AS SERINE PROTEASE INHIBITORS, PARTICULARLY NS3-NS4A HCV PROTEASE | 2004 |
|
RU2440368C2 |
| MODIFIED CYCLOSPORIN THAT CAN BE USED AS PRODRUG AND ITS USING | 2002 |
|
RU2290196C2 |
| NOVEL CYCLOSPORIN DERIVATIVES FOR TREATMENT AND PREVENTION OF VIRAL INFECTIONS | 2011 |
|
RU2601742C2 |
| HETEROARYL COMPOUNDS AND USING THEM | 2009 |
|
RU2536584C2 |
| NONIMMUNOSUPPRESSIVE CYCLOSPORINE FOR TREATING CONGENITAL ULLRICH MYOPATHY | 2008 |
|
RU2462262C2 |
| CYCLOPAMINE ANALOGUES AND METHODS OF THEIR APPLICATION | 2005 |
|
RU2403256C2 |
| CYCLOSPORIN DERIVATIVES, SUBSTITUTED WITH 3-ETHER AND 3-THIOETHER FOR TREATING AND PREVENTING INFECTIOUS HEPATITIS C | 2005 |
|
RU2399628C2 |
| METHODS OF OBTAINING AMINOALKYLGLUCOSAMINIDPHOSPHATES AND DISACCHARIDE IMMUNOEFFECTORS AND THEIR INTERMEDIATE COMPOUNDS | 2003 |
|
RU2340621C2 |
| INHIBITORS OF SERINE PROTEASES, IN PARTICULAR, HC-3-HC4A PROTEASE | 2004 |
|
RU2412198C2 |
