NITROGEN-CONTAINING SPIROCYCLIC COMPOUND AND ITS APPLICATION IN MEDICINE Russian patent published in 2017 - IPC C07D487/04 A61K31/519 A61P35/00 A61P37/06 A61P37/02 A61P37/08 A61P17/06 A61P19/02 A61P27/04 A61P27/16 A61P27/00 A61P27/14 

FIELD: pharmacology.

SUBSTANCE: compounds can be used to prepare a medicament for treatment or prevention of a disease selected from the group consisting of organ transplant rejection, graft versus host transplantation, autoimmune disease, allergic diseases and chronic myeloproliferative disease. The disease can be selected from rheumatoid arthritis, psoriasis, atopic dermatitis or a disease caused by dry eyes. In the general formula

R^a is the same or different and each represents (1) C_1-6 alkyl or (2) a halogen atom, n1 is an integer selected from the integers from 0 to 2, R^b are the same or different and each represents (1) C_1-6 alkyl or (2) halogen atom, n2 is an integer selected from the integers from 0 to 2, m1 is an integer selected from the integers from 0 to 3, m2 is an integer selected from the integers from 1 to 4, X^a=X^b is (1) CH=CH, (2) N=CH or (3) CH=N, X is (1) a nitrogen atom or (2) C-R^d, where R^d is a hydrogen atom or halogen atom, R^c is a group selected from the following groups (1)-(6): (1) a hydrogen atom, (2) C_1-6 alkyl, optionally substituted with 1-5 same or different substituents selected from the following group A, (3) -C(=O)-R^c1, (4) -C(=O)-O-R^c2, (5) -C(=O)-NR^c3R^c4, where R^c1, R^c2, R^c3, R^c4 are the same or different and each represents (i) a hydrogen atom or (ii) C_1-6 alkyl, optionally substituted with 1-5 same or different substituents selected from the following group A, or (6) a group of the following formula

in which Y^a is a group selected from the following groups (i) to(iii) (i) C_1-6 alkylene, (ii) -C(=O)- or (iii) -S(=O)-O-, ring T is (i) a phenyl, (ii) C_3-10 cycloalkyl or (iii) a saturated monoheterocyclyl, which contains 1 nitrogen atom and carbon atoms, and the number of atoms, constituting the ring, is 3-7, R^c5 is the same or different and each represents (i) cyano, or (ii) a nitro group, p is an integer selected from the integers from 0 to 1, group A is a group, consisting of (a) a hydroxyl, (b) C_1-6 alkoxy, (c) a cyano, (d) C_1-6 alkoxycarbonyl, (e) C_1-6 alkylcarboxylic and (f) C_2-6 alkenylacyl.

EFFECT: increased efficiency of treatment.

60 cl, 33 tbl, 8 ex