HIGHLY-DISPERSIVE EMULSION BASED ON PERFLUORORGANIC COMPOUNDS WITH GAS TRANSPORTATION PROPERTIES Russian patent published in 2017 - IPC A61K31/02 A61K31/08 A61K9/107 A61P7/00 

Abstract RU 2631608 C1

FIELD: pharmacology.

SUBSTANCE: emulsion contains a base in the form of a perfluoroorganic compound, namely a mixture of oxapperfluoroalkyl bromides of the formula: C2F5O-[CF2CF(CF3)O]n-CF2CF2Br, where n is 1 to 5, the specific gravity is 1.78-1.81 g/cm3, boiling point at atmospheric pressure is not more than 142°C, an emulsifying-stabilizing additive in the form of a block copolymer of ethylene oxide and propylene oxide with a molecular weight of 6000-13000 Da, a nonionic surfactant in the form of fluoroaliphatic ether with a density of 1.1-1.17 g/cm3, a co-emulsifier with stabilizing properties based on phospholipid and physiological solution, with the following ratio of components in the emulsion, vol. %: basis 4.5-45.0; emulsifying-stabilizing additive 0.2-8.0; fluoroaliphatic ether 10-3-10-2; co-emulsifier 0.05-0.50; physiological solution the rest.

EFFECT: technically and environmentally safe manufacturing technology, high stability under different temperature conditions, required dynamic oxygen capacity.

6 cl, 1 tbl, 3 ex

Similar patents RU2631608C1

Title Year Author Number
EMULSION OF PERFLUOROORGANIC COMPOUNDS WITH GAS TRANSPORT PROPERTIES 2011
  • Fejzulova Rajsja Kurban Galievna
  • Khromov Arkadij Valentinovich
  • Kalinichenko Alla Nikolaevna
  • Vorozhtsov Georgij Nikolaevich
  • Khan Ir Gvon
  • Moroz Viktor Vasil'Evich
  • Golubev Arkadij Mikhajlovich
  • Reshetnjak Vasilij Ivanovich
  • Danilenko Larisa Viktorovna
  • Bezulenko Valentina Nikolaevna
  • Soboleva Ekaterina Aleksandrovna
  • Karetenkova Aleksandra Vladimirovna
RU2469714C1
GAS TRANSPORT PERFLUOROCARBON HAEMOCORRECTOR AND METHOD FOR PRODUCTION THEREOF 2021
  • Vorobev Sergej Ivanovich
RU2775474C1
PERFLUORINATED BLOOD SUBSTITUTE - GAS TRANSPORT DONOR BLOOD SUBSTITUTE: FORMULATION AND TREATMENT 2012
  • Vorob'Ev Sergej Ivanovich
RU2518313C2
EMULSION OF PERFLUOROORGANIC COMPOUNDS WITH GAS TRANSMISSION PROPERTIES SURFACTANT OF SUCH EMULSION AND METHOD FOR PRODUCTION THEREOF 2002
  • Kalinichenko Alla Nikolaevna
  • Kaptsov Vladimir Vasil'Evich
  • Lazarev Mikhail Ivanovich
RU2305543C2
METHOD FOR PREPARING STERILE NANOEMULSION OF PERFLUORORGANIC COMPOUNDS 2014
  • Pushkin Sergej Jur'Evich
RU2557933C1
COMPOSITION BASED ON PERFLUOROORGANIC COMPOUND EMULSION FOR MEDICAL-BIOLOGICAL AIMS 1999
  • Vorob'Ev S.I.
  • Sklifas A.N.
  • Moiseenko O.M.
  • Svetlov V.N.
RU2162692C1
PHARMACEUTICAL COMPOSITION OF STERILE EMULSION OF ORGANOPERFLUORINE COMPOUNDS AND POLYELECTROLYTES AND METHOD OF ITS OBTAINING 2022
  • Muratov Dionis Vladislavovich
  • Zherebtsov Oleg Viktorovich
  • Agadzhanyan Eranui Feliksovna
  • Kamenchuk Yana Aleksandrovna
RU2811867C1
COMPOSITION OF PERFLUOROCARBON BLOOD SUBSTITUTE BASED ON EMULSION OF PERFLUOROORGANIC COMPOUNDS FOR MEDICAL-BIOLOGICAL AIMS 2001
  • Vorob'Ev S.I.
RU2199311C2
PERFLUORINATED GAS-TRANSFERRING EMULSION FOR MEDICAL AND BIOLOGICAL PURPOSES, COMPOSITION, METHOD OF OBTAINING AND PHARMACEUTICAL THEREOF (VERSIONS) 2006
  • Vorob'Ev Sergej Ivanovich
RU2367415C2
2-BROMOTETRAFLUOROETHYLPERFLUOROALKYL ESTERS FOR PRODUCING EMULSIONS FOR MEDICAL AND BIOLOGICAL PURPOSES 2017
  • Maevskij Evgenij Ilich
  • Igumnov Sergej Mikhajlovich
  • Sterlin Sergej Rafailovich
  • Tyutyunov Andrej Aleksandrovich
RU2696871C2

RU 2 631 608 C1

Authors

Abramyan Ara Arshavirovich

Beklemyshev Vyacheslav Ivanovich

Makhonin Igor Ivanovich

Igumnov Sergej Mikhajlovich

Sterlin Sergej Rafailovich

Tyutyunov Andrej Aleksandrovich

Andronova Elena Gennadevna

Dryn Olga Ivanovna

Dates

2017-09-25Published

2016-10-11Filed