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2 631 792

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IPC

C12N5/10(2006-01-01)

(21) (22)

Application

2016100500, 2016-01-11

(24)

Start date

2016-01-11

(22)

Actual filing date

2016-01-11

(45)

Published

2017-09-26

(72)

Inventor

Sennikov Sergej VitalevichKurilin Vasilij VasilevichShevchenko Yuliya AleksandrovnaKhristin Aleksandr AleksandrovichSidorov Sergej Vasilevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Institut Fundamentalnoj I Klinicheskoj Immunologii"

METHOD FOR OBTAINING OF MATURE ANTIGEN-ACTIVATED DENDRITIC CELLS WITH TRANSFECTION OF TUMOUR CELLS RNA OF BREAST CANCER Russian patent published in 2017 - IPC C12N5/10

Abstract RU 2631792 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to a method for obtaining of mature antigen-activated dendritic cells (DC) by transfection of the breast cancer tumour cells RNA, and can be used in medicine. Mature antigen-activated DCs are obtained through a combination of magnetic transfection of breast cancer tumour cells RNA at a ratio of 0.3 μg RNA to 0.3 μl of suspended magnetic particles with a stimulator of maturation at a dose of 25 ng/ml for 24 hours.

EFFECT: invention allows effective stimulation an antitumour cytotoxic immune response against breast cancer cells.

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RU 2 631 792 C2

Authors

Sennikov Sergej Vitalevich

Kurilin Vasilij Vasilevich

Shevchenko Yuliya Aleksandrovna

Khristin Aleksandr Aleksandrovich

Sidorov Sergej Vasilevich

Dates

2017-09-26—Published

2016-01-11—Filed