NEW INHIBITORS OF SERINE-THREONINE KINASES, INCLUDING FOR TREATMENT OF ONCOLOGICAL DISEASES AND TUBERCULOSIS Russian patent published in 2017 - IPC C07D401/14 C07D417/14 A61K31/4155 A61K31/427 A61K31/40 A61K31/44 A61K31/506 A61P31/06 A61P35/00 

FIELD: pharmacology.

SUBSTANCE: invention relates to compounds of the general formula

or

n=0-2; A is independently selected and is a 5-7-membered aromatic heterocycle containing 1-2 N atoms and 0-1 S atom; A contains 0-2 R substituents; R is independently selected and represents methyl or ethyl; B is independently selected and represents phenyl, 5-6-membered heteroaryl cycle containing 0-2 N atoms and 0-1 S atom, or 5-6-membered cycloalkyl containing 0-2 N atoms and 0-1 S atom; B contains 0-3 R¹ substituents; C is independently selected and represents phenyl, -NH₂, -NH-C_1-3-alkyl, -NH (C_1-3-alkyl) C_1-3-alkyl, a 5-6-membered heteroaryl cycle containing 0-2 N atoms and 0-1 S atom, or a 5-6-membered cycloalkyl containing 0-2 N atoms and 0-1 S atom; C contains 0-3 R¹ substituents; R¹ is independently selected and represents -C_1-6-alkyl, halogen, phenyl, -C_5-7-heteroaryl containing 1-2 N atoms and 0-1 S atom, -COOH, -CONH₂, -NH₂ or -NHR²; R² is independently selected and represents -C_1-6-alkyl, -C (O) -C_1-8-alkyl; the linker X is independently selected and is -CH₂-, -C(=O)-CH₂- or -CH₂-O-group; the linker Q is independently selected and represents -NH- or -NH-C(O) -group; the Y linker is independently selected and represents -O-(CH₂) _m or -C(O)-NH-(CH₂)_m, where m=1-3; Z is independently selected and represents -CH₂- group or an oxygen atom.

EFFECT: compounds are prospective for use in the therapy of diseases associated with the activity of serine-threonine kinases.

13 cl, 2 tbl, 16 ex