SELECTIVE INHIBITORS OF Haspin kinase Russian patent published in 2015 - IPC C07D471/04 C07D487/04 A61K31/437 A61K31/444 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of organic chemistry, namely to novel hetericyclic compounds of general formula or to its tautometric form, or to its pharmaceutically acceptable salt, where 1-2 of X₁, X₂, X₃, X₄, X₅, X₆ is selected from N, and the remaining ones represent C, X₇ is selected from N or CH; each of X₈, X₉, X₁₀ and X₁₁ is independently selected from N or CH on condition that fragment can simultaneously contain one or two nitrogen atoms; R₁, R₂, R₃ and R₄ are selected from H, 6-membered aryl, CF₃, halogen; R₅, R₆, R₇ represent C₁-alkyl on condition that X₉, X₁₀ or X₁₁ in this case respectively equals C; "A" can represent simple bond or bridging ethyne moiety; Y can represent simple bond or is independently selected from methylene or ethylene bridging moieties; moiety Z is independently selected from no-substituted or substituted in nitrogen atom heterocycloalkyl or is non-substituted or substituted cycloalkyl on condition that N (nitrogen) equals C (carbon): , where R₉ is selected from CH₂OH, CON(R₁₅, R₁₆), where R₁₅, R₁₆ can independently represent H, C₁-alkyl, Het represents N, n=1, n₁=3; R₈ is selected from H, C_1-6-alkyl, C₁-alkylcarbonyl, derivetives of arylacetic acid of general structure: , where methylheteroaryls of general structure: , where derivatives of alkylsulphonyls of general structure where R₁₄=Alk, with Alk representing C₁-alkyl, or to 2-methylamino-1-{3-[6-(6-chloroimidazo[1,2-a]pyridin-3-yl)pyridin-2-ylmethyl]-1-oxa-8-azaspiro]4.5]decan-8-yl}-ethanol dihydrochloride, or to 6-(6- chloroimidazo[1,2-a]pyridin-3-yl)-1',4',5',6'-tetrahydro-2'H-[2,3']bipyridinyl-3'-carboxylic acid dihydrochloride, or to 6-(6- chloroimidazo[1,2-a]pyridin-3-yl)-1',4',5',6'-tetrahydro-2'H-[2,3']bipyridinyl-3'-carboxylic acid dimethylamine dihydrochloride. Invention also relates to pharmaceutical composition based on claimed compound and to method of Haspin kinase inhibition.

EFFECT: obtained are novel compounds, possessing useful biological properties.

5 cl, 7 tbl, 35 ex