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2 468 027

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IPC

C07D491/04(2006-01-01)

C07D495/04(2006-01-01)

A61K31/519(2006-01-01)

A61K31/5377(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2009125897/04, 2007-12-05

(24)

Start date

2007-12-05

(22)

Actual filing date

2007-12-05

(45)

Published

2012-11-27

(72)

Inventor

Bejliss TrejsiChukauri IrinaFoulks AdrianOksenford SalliVan' Nan' ChiKastanedo ZhorzhettGoldsmit RichardGanzner DzhenetKheffron TimMat'E SimonOlivero AlanStehjben StivenSaterlin Daniel P.Chzhu Bin-Jan'

(73)

Holder

F. Khoffmann-Lja Rosh AgDzhenentek, Ink.

PHOSPHOINOSITIDE-3-KINASE INHIBITORS AND METHODS FOR USE THEREOF Russian patent published in 2012 - IPC C07D491/04 C07D495/04 A61K31/519 A61K31/5377 A61P35/00

Abstract RU 2468027 C2

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula

where X is S or O, mor is a morpholine group, and R³ is a monocyclic heteroaryl group, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, which are used to modulate lipid kinase activity, including PI3K, and for treating lipid kinase mediated disorders such as cancer.

EFFECT: obtaining compounds which are used to modulate lipid kinase activity, including PI3K, and for treating lipid kinase mediated disorders such as cancer.

27 cl, 1 tbl, 354 ex

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RU 2 468 027 C2

Authors

Bejliss Trejsi

Chukauri Irina

Foulks Adrian

Oksenford Salli

Van' Nan' Chi

Kastanedo Zhorzhett

Goldsmit Richard

Ganzner Dzhenet

Kheffron Tim

Mat'E Simon

Olivero Alan

Stehjben Stiven

Saterlin Daniel P.

Chzhu Bin-Jan'

Dates

2012-11-27—Published

2007-12-05—Filed