INACTIVATED VACCINES AGAINST VARICELLA-ZOSTER VIRUS, METHODS FOR THEIR PRODUCTION AND APPLICATION Russian patent published in 2017 - IPC A61K39/25 A61P31/22 

FIELD: pharmacology.

SUBSTANCE: group of inventions can be used to produce a vaccine against the varicella zoster virus (VZV). The pharmaceutical composition comprises a therapeutically effective amount of an inactivated varicella-zoster virus (VZV) and a pharmaceutically acceptable carrier, wherein VZV is inactivated by gamma irradiation at a dose of 16 to 26 kGy and wherein the infectivity of VZV is ≤0.040 plaque forming units (PFU)/ml, and where the inactivated VZV elicits an immune response against VZV when administered to a patient. The group of inventions refers to a method for production of an inactivated vaccine against VZV, as well as a method for herpes zoster treatment in a patient, comprising pharmaceutical composition administration to the patient.

EFFECT: use of this group of inventions allows to obtain a pharmaceutical composition that possesses a complex of two properties, safety of use in patients with weakened immunity and immunogenicity, the necessary dose of irradiation from 16 to 26 kGy ensures that these two criterial conditions are met.

20 cl, 10 ex, 7 dwg