FIELD: biotechnology.
SUBSTANCE: described is a method of producing a whole-virion vaccine by treating poliomyelitis virus with high-energy electrons, the energy of which is in range of 5 to 10 MeV. Method includes steps of producing a liquid containing poliomyelitis virus with infectious activity of not less than 8.0 lg TCD50/ml, and irradiating the obtained liquid containing the poliomyelitis virus with a beam of high-energy electrons, wherein the radiation dose is in range of 15 to 50 kGy.
EFFECT: creation of a simple and highly productive method of producing a highly effective whole-virus vaccine against poliomyelitis virus.
7 cl, 3 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING VACCINE PREPARATION FROM WHOLE VIRUSES OR BACTERIA | 2023 |
|
RU2822827C1 |
| STRAIN "LT-21/07" OF AUJESZKY VIRUS FOR MANUFACTURING VACCINES AND DIAGNOSTIC PREPARATIONS | 2010 |
|
RU2439150C1 |
| STRAIN OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS FOR PRODUCTION OF DIAGNOSTIC AND/OR VACCINE PREPARATIONS | 2005 |
|
RU2295567C1 |
| INACTIVATED EMULSION VACCINE AGAINST SWINE'S REPRODUCTIVE-RESPIRATORY SYNDROME | 2006 |
|
RU2316346C2 |
| METHOD OF TREATMENT OF RADIATION DAMAGES OF BODY | 2018 |
|
RU2675598C1 |
| METHOD OF PRODUCING VACCINE AGAINST BLUETONGUE OF LARGE AND SMALL CATTLE (VERSIONS) AND VACCINE AGAINST BLUETONGUE OF LARGE AND SMALL CATTLE | 2008 |
|
RU2391114C1 |
| COMBINED METHOD FOR BONE IMPLANTS STERILISATION | 2016 |
|
RU2630464C1 |
| SORBED INACTIVE DRY VACCINE AGAINST INFECTIOUS RHINOTRACHEITIS OF CATTLE | 2016 |
|
RU2644339C2 |
| NADL-ARRIAH VIRUS STRAIN OF BOVINE VIRAL DIARRHOEA FOR MAKING BIOPREPARATIONS FOR DIAGNOSIS, SPECIFIC PREVENTION AND TREATMENT OF BOVINE VIRAL DIARRHOEA | 2010 |
|
RU2449013C2 |
| CATTLE VIRAL DIARRHOEIA VACCINE | 2011 |
|
RU2457859C1 |
