METHOD FOR MEASUREMENT OF ANTIBODIES TO WT1 Russian patent published in 2017 - IPC G01N33/543 G01N33/574 

FIELD: medicine.

SUBSTANCE: method comprises an immunoassay using a polypeptide with antigenicity against an antibody to WT1 selected from i) a polypeptide comprising a sequence with amino acids at 294-449 positions of the SEQ ID NO: 1 sequence and ii) a polypeptide comprising an amino acid sequence with deletion, substitution or addition of one to several amino acids in the amino acid sequence constituting the polypeptide i). The group of inventions also relates to a method for WT1-related disease diagnostics comprising measurement of an antibody against WT1 in a sample and diagnosing of the presence of a WT1-related disease if the concentration of an antibody against WT1 is significantly increased compared to the anti-WT1 antibody concentration in a healthy individual; a method for prediction of the patient's response to therapy with WT1 vaccine; a reagent for measurement of the antibody to WT1 in the sample.

EFFECT: high accuracy and sensitivity in determination of a group of cancer patients.

10 cl, 5 ex, 12 dwg, 1 tbl