APTAMER AGAINST NGF AND ITS APPLICATION Russian patent published in 2017 - IPC C12N15/115 C12N15/09 A61K31/712 A61P29/00 A61P37/04

Abstract RU 2633510 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to an aptamer specifically binding to a nerve growth factor (NGF), and can be used in medicine as an anti-inflammatory or analgesic. The invention allows to obtain an aptamer capable of forming a secondary structure represented by the formula (I), where N is nucleotid selected from the group consisting of A, G, C and U. Each of N14 and N24, N31 and N41, and N39 and N49 forms a Watson-Cric base pair, and the remaining nucleotides of formula (I) are capable of forming a stalk structure.

EFFECT: invention provides an aptamer capable of inhibiting NGF activity at IC₅₀ 1 nM or less.

5 cl, 5 dwg, 5 tbl, 18 ex

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RU 2 633 510 C2

Authors

Tszin Lin

Khiramatsu Khisanao

Dates

2017-10-12—Published

2012-09-28—Filed