DYETHERNED PHENYLAMINOPYRIMIDINE AND PHARMACEUTICAL COMPOSITION CONTAINING SUCH CONNECTION Russian patent published in 2017 - IPC C07D413/12 A61K31/5377 

FIELD: pharmacology.

SUBSTANCE: invention relates to the deuterated phenylamino-pyrimidine of formula (I) or its pharmaceutically acceptable salts: . In the formula (I) R¹, R², R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, R¹⁸, R¹⁹, R²⁰, R²¹ and R²² are each independently hydrogen or deuterium; R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹, R¹⁰ and R¹¹ are each independently hydrogen; R¹² is hydrogen; Provided that at least one of R¹, R², R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, R¹⁸, R¹⁹, R²⁰, R²¹ or R²² are deuterated or deuterium. The invention also relates to a pharmaceutical composition for inhibiting JAK kinase and to the use of compounds for the preparation of a pharmaceutical composition.

EFFECT: new compounds of formula (I) having the properties of a JAK kinase inhibitor have been obtained.

9 cl, 1 dwg, 4 tbl, 13 ex