AZAINDOLYL PYRIDONE AND DIAZAINDOLYL PYRIDONE Russian patent published in 2023 - IPC C07D471/04 A61K31/444 A61K31/496 A61K31/506 A61K31/5377 A61P35/00 A61N5/10 

FIELD: organic chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, namely to a heterocyclic compound of formula (I) or a pharmaceutically acceptable salt thereof, where X is N or CR¹; R¹ is selected from H, C₁-C₃ alkyl, C₃-C₆ cycloalkyl, cyano, phenyl, monocyclic heteroaryl, wherein said phenyl and said heteroaryl are optionally and independently substituted with one substituent selected from C₁-C₃ haloalkyl and C₁-C₃ alkyl; R² is a hydrogen atom; R³ is selected from A, phenyl and monocyclic heteroaryl, wherein said phenyl and said heteroaryl are optionally and independently substituted with one R⁴; R⁴ is independently selected from halo, C₁-C₆ alkyl and C₁-C₆ haloalkyl; R⁷ is C₁-C₆ alkyl, said C₁-C₆ alkyl optionally substituted with one R⁸; R⁸ is selected from phenyl optionally substituted with one R⁹; R⁹ is selected from halogen; A represents

R¹⁰ is selected from hydrogen, C₁-C₃ haloalkyl and phenyl, and provided that when R¹⁰ is phenyl, X is N or CH, Y is CH₂, NSO₂R⁷, O or a bond; where the specified heteroaryl represents an aromatic group of carbon atoms in which one to two carbon atoms are replaced by one or two heteroatoms independently selected from nitrogen, oxygen and sulfur. The invention also relates to the use of a compound of formula (I), a method for inhibiting vacuolar sorting protein 34 (Vsp34) and a pharmaceutical composition based on it.

EFFECT: development of potent Vsp34 inhibitors having the structure of formula (I) which may be useful in the treatment of cancer or type II diabetes.

29 cl, 2 tbl, 90 ex