PYRIDINAMINPYRIDONES AND PYRIMIDINAMINPYRIDONES Russian patent published in 2023 - IPC C07D401/04 C07D401/14 C07D413/14 C07D417/14 A61K31/506 A61P3/10 A61P35/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R¹ is phenyl or a monocyclic 5–6 membered heteroaryl selected from the group consisting of imidazole, pyrazole, thiazole, oxazole and pyrimidine, each optionally substituted with C₁-C₆ alkyl; R² represents a hydrogen atom; R³ is selected from the group consisting of A, phenyl and a monocyclic heteroaryl selected from pyrazole or pyridine, each of said phenyl and heteroaryl rings optionally substituted with one or two R⁴, R⁵, R⁶ and R⁷; R⁴, R⁵, R⁶ and R⁷ are independently selected from halogen, C₁-C₆ alkyl, C₁-C₆ haloalkyl and C₁-C₆ haloalkoxy; R⁹ is C₁-C₆ alkyl, with each C₁-C₆ alkyl optionally substituted with one R¹⁰; R¹⁰ is phenyl, the said phenyl optionally substituted with one R¹¹; R¹¹ is halogen; A represents

R¹² represents a hydrogen atom or C₁-C₃haloalkyl; Y is selected from the group consisting of CH₂, NSO₂R⁹ and O; and Z is CH or N. The invention also relates to a pharmaceutical composition for inhibiting Vps34 based on these compounds.

EFFECT: obtaining new compounds and a pharmaceutical composition based on them which can be used in medicine as effective agents for the treatment of prostate cancer.

28 cl, 2 tbl, 69 ex