FIELD: pharmacology.
SUBSTANCE: use of a nucleosome-protein adduct as a biomarker in a blood, serum or plasma sample for cancer diagnosis, where the protein bound to a nucleosome contains a transcription factor or a chromatin-modifying enzyme, is proposed. Also, the possibility of cancer detection or diagnosis in an individual, individual assessment regarding the applicability of medical treatment and monitoring of individual treatment are proposed.
EFFECT: ability to diagnose cancer, such as: colon cancer, lung cancer, pancreatic cancer, breast cancer, prostate cancer, by measuring the level of circulating extracellular adducts of nucleosome-HMGB-1 and nucleosome-EZH2 in a biological blood serum or plasma sample, derived from the individual.
20 cl, 11 dwg, 12 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF DETECTING NUCLEOSOMES CONTAINING HISTONE VERSIONS | 2012 |
|
RU2716494C2 |
| METHOD OF NUCLEOSOMES DETECTION CONTAINING NUCLEOTIDES | 2012 |
|
RU2687483C2 |
| HUMAN EZH2 INHIBITORS AND METHODS OF APPLICATION THEREOF | 2011 |
|
RU2618475C2 |
| HUMAN EZH2 INHIBITORS AND METHODS FOR APPLICATION THEREOF | 2011 |
|
RU2765155C2 |
| TEST-SYSTEM FOR CHEMICAL COMPOUNDS SCREENING FOR INHIBITING ACTIVITY AGAINST PARP-1 | 2016 |
|
RU2649767C1 |
| METHOD AND DEVICE FOR BLOOD PURIFICATION FROM FREE-CIRCULATING DNA | 2018 |
|
RU2779220C2 |
| METHOD OF TESTING SUBSTANCES THAT AFFECT AGING PROCESS | 2011 |
|
RU2497950C2 |
| METHOD FOR SCREENING OF ANTITUMOR PREPARATIONS - PARP1 INHIBITORS BASED ON BIOCHEMICAL METHODS OF ANALYSIS | 2015 |
|
RU2639535C2 |
| CANCER BIOMARKERS | 2007 |
|
RU2460075C2 |
| BIOLOGICAL MARKERS FOR IDENTIFYING PATIENTS FOR TREATMENT WITH VEGF ANTAGONISTS | 2013 |
|
RU2659173C2 |
