TEST-SYSTEM FOR CHEMICAL COMPOUNDS SCREENING FOR INHIBITING ACTIVITY AGAINST PARP-1 Russian patent published in 2018 - IPC G01N33/52 

Abstract RU 2649767 C1

FIELD: medicine.

SUBSTANCE: group of inventions concerns a test system for chemical compounds screening for inhibitory activity against PARP-1 based on FRET microscopy of single particles (spFRET), which is a mixture comprising a mononucleosome complex on a nucleosome-positioning DNA template labeled with a pair of fluorophores, forming donor-acceptor pairs to implement the FRET effect; PARP-1 protein and its substrate - NAD+. The group of inventions also relates to a method for chemical compounds screening for inhibitory activity against PARP-1 based on FRET microscopy of single particles.

EFFECT: group of inventions provides detection of compounds directed to PARP-1 and capable of inhibiting its activity.

12 cl, 1 ex, 8 dwg

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Authors

Studitskij Vasilij Mikhajlovich

Feofanov Aleksej Valerevich

Sultanov Daniel Chingizovich

Kudryashova Kseniya Sergeevna

Gerasimova Nadezhda Sergeevna

Malyuchenko Nataliya Valerievna

Dates

2018-04-04Published

2016-12-07Filed