FIELD: medicine.
SUBSTANCE: device for apheresis is proposed, containing one or more affine matrices capable of capturing free-circulating DNA (hereinafter – fcDNA) bound to nucleosomes, fcDNA bound to exosomes, and unbound fcDNA from subject’s blood or plasma, wherein the specified one or more affine matrices contain DNA-binding polymer, DNA-binding protein, an anti-histone antibody, an anti-nucleosome antibody, a DNA-intercalating agent, an anti-DNA antibody, or any combination thereof. A method for the reduction in a level of free-circulating DNA (fcDNA) in subject’s blood, and a method for the treatment of a diseases characterized by increased levels of circulating DNA in subject’s blood are proposed.
EFFECT: proposed group of inventions provides for a positive effect on the treatment of diseases characterized by increased levels of circulating fcDNA in blood.
24 cl, 9 dwg, 10 tbl, 21 ex
| Title | Year | Author | Number |
|---|---|---|---|
| EXOSOME RECOVERY KIT | 2023 |
|
RU2824663C1 |
| METHOD OF DETECTING NUCLEOSOMES CONTAINING HISTONE VERSIONS | 2012 |
|
RU2716494C2 |
| METHOD OF NUCLEOSOMES DETECTION CONTAINING NUCLEOTIDES | 2012 |
|
RU2687483C2 |
| METHOD FOR NUCLEOSOMES ADDUCTS DETECTION | 2012 |
|
RU2634266C2 |
| METHOD FOR ISOLATION AND ANALYSIS OF EXOSOMES | 2022 |
|
RU2788198C1 |
| VNS-Met-HISTONES | 2008 |
|
RU2498997C2 |
| BIS-MET-HISTONES | 2008 |
|
RU2640247C2 |
| METHOD OF ISOLATING VIRUS FROM BLOOD BY LECTIN HEMODIALYSIS | 2004 |
|
RU2353399C2 |
| METHODS AND SETS RELATED TO CAPTURE OF CA-IX-POSITIVE EXOSOMES | 2018 |
|
RU2770592C2 |
| METHOD AND SYSTEM TO REMOVE SOLUBLE TNFRI, TNFR2 AND IL2 IN PATIENTS | 2005 |
|
RU2378016C2 |
