METHOD FOR COMBINED TREATMENT OF PATIENTS WITH LARYNGEAL AND LARYNGOPHARYNGEAL CANCER Russian patent published in 2017 - IPC A61N5/10 A61K31/282 A61K31/337 A61P35/00 

FIELD: medicine.

SUBSTANCE: neoadjuvant chemotherapy with cisplatin and subsequent radiotherapy in the mode of dose multifractionation is performed with a 4-5 hours interval between fractions followed by an evaluation of treatment effectiveness. At that, for patients who have achieved complete regression, radiotherapy is continued to a radical dose of 60-65 isoG. Patients for whom the treatment effect is assessed as partial regression and process stabilization, are subject to surgical intervention. Neoadjuvant therapy is carried out in the form of 2 courses with an interval of 3-4 weeks, where the course includes administration of docetaxel at a dose of 75 mg/m² and cisplatin at a dose of 75 mg/m². Subsequently, radiotherapy is performed in a multifraction mode of a dose of 1.3 Gy, 2 times a day, with an effect on SOD = 40 Gy estimated by the isoelectric effect.

EFFECT: reduced number of complications due to reduced toxicity from chemotherapy courses, larynx preservation, decreased likelihood of distant metastases development.

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