SYNTHETIC IMMUNOGEN FOR PROTECTION AND TREATMENT OF PSYCHOACTIVE SUBSTANCES ADDICTION Russian patent published in 2017 - IPC A61K39/385 A61K39/39 A61K47/50 A61K47/58 A61P25/30 A61P25/36 

FIELD: medicine.

SUBSTANCE: invention relates to an immunogen that is a conjugate of a macromolecular carrier selected from the group consisting of a natural protein, an artificial protein, an oligopeptide, a polypeptide, a carbohydrate, a lipid or a nucleotide, and a hapten selected from a narcotic or psychotropic compound. The conjugate is covalently bound to the synthetic polymer by means of a carboxymethyl linker connecting the nitrogen atoms of the synthetic polymer pyridine units with amino groups or macromolecular carrier hydroxyl groups, copolymer of the 2-methyl-5-vinylpyridine and N-vinylpyrrolidone of the general formula I

:

where n is 25 to 50 moll. %, and the viscosity-average molecular weight Mη is equal to 15-45 kDa; or copolymer of 4-vinylpyridine, 2-methyl-5-vinylpyridine and N-vinylpyrrolidone of the general formula II:

,

where (m+k) is 20-90 moll. %, the proportion of the monomeric units of 4-vinylpyridine is 0.05 (m+k) to 0.30 (m+k), and the viscosity-average molecular weight Mη is equal to 15-250 kDa, is used as the synthetic polymer.

EFFECT: effective immune response.

4 cl, 27 ex, 3 tbl