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(19)

(11)

2 636 050

(13)

(51)

IPC

C07D401/14(2006-01-01)

C07D413/14(2006-01-01)

C07D401/04(2006-01-01)

C07D403/04(2006-01-01)

C07D403/14(2006-01-01)

C07D413/04(2006-01-01)

A61K31/496(2006-01-01)

A61K31/5377(2006-01-01)

A61K31/4025(2006-01-01)

A61K31/41(2006-01-01)

A61P7/02(2006-01-01)

(21) (22)

Application

2014152276, 2013-05-23

(24)

Start date

2013-05-23

(22)

Actual filing date

2013-05-23

(45)

Published

2017-11-20

(72)

Inventor

Imagava AkiraKondo TakasiNisiyama TajkhejKortni StivYarnold KrisItikhara OsamuFlenegan Styuart

(73)

Holder

Ono Farmasyutikal Ko., Ltd.

SUBSTITUTED PYRROLIDINES AS XIa FACTOR INHIBITORS FOR THROMBOEMBOLIC DISEASES TREATMENT Russian patent published in 2017 - IPC C07D401/14 C07D413/14 C07D401/04 C07D403/04 C07D403/14 C07D413/04 A61K31/496 A61K31/5377 A61K31/4025 A61K31/41 A61P7/02

Abstract RU 2636050 C2

FIELD: pharmacology.

SUBSTANCE: invention relates to compounds of the general formula

, their pharmaceutically acceptable salts, pharmaceutical compositions containing the said compounds.

EFFECT: compounds of general formula I are XIa factor inhibitors and are suitable for thromboembolic diseases prevention or treatment.

22 cl, 1 tbl, 115 ex

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RU 2 636 050 C2

Authors

Imagava Akira

Kondo Takasi

Nisiyama Tajkhej

Kortni Stiv

Yarnold Kris

Itikhara Osamu

Flenegan Styuart

Dates

2017-11-20—Published

2013-05-23—Filed