FIELD: biotechnology.
SUBSTANCE: invention can be used in medicine to induce anti-tumour immunity against expression of Lck, WHSC2, SART2, SART3, UBE2V, EGFR, PTHrP or MRP3 cancer. A peptide is obtained from 4 CTL epitopes of cancer antigens linked through amino acid linkers. The resulting peptide is used to stimulate peripheral blood lymphocytes to obtain a combination of CTL specific for the cancer antigen.
EFFECT: invention allows to obtain a peptide vaccine for cancer treatment in a wide range of patients without the necessity of HLA-typing and regardless of the HLA types in patients.
11 cl, 17 dwg, 4 tbl, 5 ex
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Authors
Dates
2017-11-23—Published
2014-10-20—Filed