PHARMACEUTICAL COMPOSITIONS BASED ON SHK AND METHODS FOR THEIR PRODUCTION AND USE Russian patent published in 2017 - IPC A61K38/16 A61K38/17 A61P17/00 

FIELD: pharmacology.

SUBSTANCE: pharmaceutical composition contains a pharmaceutically acceptable salt of ShK polypeptide, consisting of a sequence of SEQ ID No. 1 attached to chemical particle through aminoethyloxiethyloxiacetyl (AEEAc) linker. The said chemical particle is selected from the group consisting of AEEAc-L-Pmp(OH₂); AEAAS-D-Pmp(OH₂); AEAAC-D-Pmp (OH, Et); AEAs-L-Pmp(Et₂); AEAAC-D-Pmp(Et₂); AEAAS-L-Tyr; AEAAS-L-Tyr(PO₃H₂); AEAAC-L-Phe(p-NH₂); AEAAS-L-Phe(p-CO₂H); AEAAS-L-aspartate; AEEAc-D-aspartate; AEESA-L-glutamate; and AEEAc-D-glutamate, and the C-terminus of the polypeptide is an acid or an amide. Also, the composition comprises a surfactant in an amount effective to dissolve the said ShK polypeptide in an aqueous carrier. The pH of the said pharmaceutical composition is 5-7.

EFFECT: articles for treatment of autoimmune diseases comprising the said composition and a method for manufacture of the said pharmaceutical composition are provided.

11 cl, 3 dwg, 6 tbl, 7 ex