FIBRE-OPTICAL NEUROINTERFACE AND METHOD FOR LONG-TERM OPTICAL REGISTRATION OF PROCESSES IN BRAIN OF LIVING FREE MOVING ANIMALS Russian patent published in 2017 - IPC A61N5/67 A61B6/00 

FIELD: physics.

SUBSTANCE: fibre-optic neurointerface includes, at least, one probe connected to a laser optical excitation system and a system for recording and measuring the response of the brain region being examined, which is connected to a personal computer equipped with software for controlling the measurement process, storing and displaying measurement results. Herewith the probe consists of two detachable parts, where the first part is a ceramic ferrule with the possibility of placing an internal fibre segment in it, intended to be fixed on the animal's skull and executed, and the second part is a reciprocal ferula with an outer fibre segment fixed in it, placed in a connecting ceramic body configured to be densely connected to the ferrule of the first part. At the same time, the inner length of the fibre is long enough to allow it to be inserted into the animal's brain at the required depth for carrying out appropriate research with optical communication with the outer fibre segment. The laser optical excitation system consists of, at least, three single-frequency lasers with different emission wavelengths for multispectral excitation provided with an external amplitude modulator of laser radiation, and the connection of the probe to the laser optical excitation system and the optical response recording system is realized by means of an external long segment of the optical fibre. The method for long-term optical recording of processes in the brain of living freely moving animals involves the installation of, at least, one probe of the claimed device in the area of the skull of the experimental animal in the projection of the brain region selected for the study and the introduction of an internal fibre segment through the ferula channel of the first part of the probe to the said site, then, after implantation of the ferula of the first part of the probe, a ferula of the second part of the probe with an outer segment of the optical fibre is attached to it by means of a connecting body for the time of measurement, then the laser source is irradiated with the indicated area of the brain, after which an optical response is detected in the registration system and the data is analyzed using an analog-to-digital converter and a computer.

EFFECT: improvement of data acquisition.

8 cl, 6 dwg